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Coordinating Center

Andrew. I.R. Maas

andrew.maas@uza.be

Lead Investigators

Rotterdam:

Ewout Steyerberg

E.Steyerberg@erasmusmc.nl

Edinburgh:

Gordon Murray

Gordon.Murray@ed.ac.uk

Antwerp:

Andrew Maas

andrew.maas@uza.be

Definition: TBI is defined as an alteration in brain function, or other evidence of brain pathology, caused by an external force. This force may be accidental or deliberate, may result from a direct hit or blow to the head or from indirect acceleration/deceleration or blast forces, may penetrate the skull or leave it intact. Whatever the cause or mechanism, some degree of brain damage occurs which may range from 'minor/mild' to 'severe/critical'. The full extent of damage is not always immediately apparent. Life threatening complications can develop after 'mild' injuries. Mortality in patients with more moderate or severe injuries is high and life long disability is common in survivors.

A silent epidemic
A deadly killer
A field in medicine with one of the highest unmet needs
Can strike us all
Changes lives forever

The IMPACT Project is focused on advancing knowledge of prognosis, trial-design and treatment in TBI.

IMPACT has

developed and validated prognostic models for classification and characterization of TBI series
participated in the development of standardization of data collection in TBI studies (common data elements).
provided evidence based recommendations for improving sensitivity and efficiency of trials in TBI

IMPACT will

continue its research efforts towards provision of further evidence in support of efforts to improve treatment.
Advise and assist in the development of clinical research programmes, investigating new treatments for TBI which could lead to better patients outcomes.