Definition: TBI is defined as an alteration in brain function,
or other evidence of brain pathology, caused by an external force.
This force may be accidental or deliberate, may result from a direct
hit or blow to the head or from indirect acceleration/deceleration or
blast forces, may penetrate the skull or leave it intact. Whatever the
cause or mechanism, some degree of brain damage occurs which may range
from 'minor/mild' to 'severe/critical'. The full extent of damage is
not always immediately apparent. Life threatening complications can
develop after 'mild' injuries. Mortality in patients with more moderate
or severe injuries is high and life long disability is common in survivors.
A silent epidemic
A deadly killer
A field in medicine with one of the highest unmet needs
Can strike us all
Changes lives forever
The IMPACT Project is focused on advancing knowledge of prognosis, trial-design
and treatment in TBI.
developed and validated prognostic models for classification and characterization
of TBI series
participated in the development of standardization of data collection in TBI studies
(common data elements).
provided evidence based recommendations for improving sensitivity and efficiency
of trials in TBI
continue its research efforts towards provision of further evidence in support of
efforts to improve treatment.
Advise and assist in the development of clinical research programmes, investigating
new treatments for TBI which could lead to better patients outcomes.