Welcome
IMPACT: International Mission for Prognosis and Analysis of Clinical Trials in TBI.
Traumatic Brain Injury (TBI) may afflict us all, but young adult males are particularly at risk. IMPACT is an international multidisciplinary effort to advance clinical research programmes in search of better treatment.
Nearly 10 years of work has resulted in the development of a prognostic calculator for establishing prognosis in individual patients, proposals for standardization of data collection in TBI studies (common data elements) and recommendations for improving the design and analysis of TBI studies. It is hoped that these recommendations will substantially increase possibilities for proving efficacy of new treatments. We greatly welcome any feedback you may have
Background
Traumatic Brain Injury (TBI) is a dynamic and heterogeneous disease in which many mechanisms and pathways can lead to secondary damage. Many different kinds of therapy and neuroprotective agents with high potential for efficacy have been developed.
Unfortunately in trials none of these have shown convincing evidence of benefit in the clinical situation with sufficient generalizibility. Some of these therapies may have been truly ineffective but the risk exists that some therapies may have been wrongly discarded due to the use of insensitive methodology in clinical trials.
The TBI population poses several complicated methodological challenges, related to the heterogeneity of the population, outcome-assessment and design issues. IMPACT is focused on tackling these head-on with the aim of providing recommendations for more powerful trials in the future.
Collaborating IMPACT institutes
Andrew I.R. Maas (Principal Investigator)
Ewout W. SteyerbergLead Investigator Rotterdam, NL
Email: H.Lingsma@erasmusmc.nl
Email: E.Steyerberg@erasmusmc.nl
Morag Leitch
Gillian McHugh
Jim Weir
Lead Investigator Edinburgh, UK
Email: Gordon.Murray@ed.ac.uk
Tony Marmarou †Lead Investigator Richmond, US 2003-2010
Statistician
- developed and validated prognostic models for classification and characterization of TBI series
- participated in the development of standardization of data collection in TBI studies (common data elements).
- provided evidence based recommendations for improving sensitivity and efficiency of trials in TBI
- continue its research efforts towards provision of further evidence in support of efforts to improve treatment.
- Advise and assist in the development of clinical research programmes, investigating new treatments for TBI which could lead to better patients outcomes.
- A silent epidemic
- A deadly killer
- A field in medicine with one of the highest unmet needs
- Can strike us all
- Changes lives forever
